Low serum levels of meteorin-like/subfatin is related to obesity and insulin resistance

Introduction: Meteorin-like (Metrnl), also known as subfatin is a newly discovered adipokine of adipocyte origin that may play role in obesity and insulin resistance. The current study aimed to investigate the association between biochemical values, demographic characteristics, resistance obese patients healthy controls.Methods: This cross-sectional included 59 with sex age-matched group 41 controls. An enzyme-linked immunosorbent assay (ELISA) was used measure serum levels Subfatin correlations Metrnl level anthropometric parameters, HOMA index, measurements were assessed.Results: BMI (p<0.001), (p=0.002), HOMA-IR score (p<0.001) significantly higher than found be lower (1.85 [1.35–5.51] ng/ml) compared controls (21.82 [12.61–27.76] (p<0.001). had negative relationship age (r =-0.250, p=0.012), weight =-0.373, p=0.001), =-0.492, HbA1c =-0.209, p=0.037), LDL =-0.264, p=0.008), =-0.223, p=0.026), glucose =-0.376, p<0.001). There positive correlation height (r=0.321, p=0.001).Conclusion: These results show decreased patients. circulating amounts hormone age, weight, height, LDL-cholesterol, glucose, hbA1c, HOMA-IR. might new biomarker resistance.Keywords: Meteorin-like/subfatin, adiposity, resistance, adipokines, biomarkers, diabetes mellitus type 2